Differences in regional air trapping in current smokers with normal spirometry

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Error in Author Affiliation. Clinical and Radiologic Disease in Smokers With Normal Spirometry.

IMPORTANCE Airflow obstruction on spirometry is universally used to define chronic obstructive pulmonary disease (COPD), and current or former smokers without airflow obstruction may assume that they are disease free. OBJECTIVE To identify clinical and radiologic evidence of smoking-related disease in a cohort of current and former smokers who did not meet spirometric criteria for COPD, for w...

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Risk of COPD with obstruction in active smokers with normal spirometry and reduced diffusion capacity.

Smokers are assessed for chronic obstructive pulmonary disease (COPD) using spirometry, with COPD defined by the Global Initiative for Chronic Obstructive Lung Disease (GOLD) as airflow limitation that is not fully reversible with bronchodilators. There is a subset of smokers with normal spirometry (by GOLD criteria), who have a low diffusing capacity of the lung for carbon monoxide (DLCO), a p...

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Gas trapping as a predictor of positive methacholine challenge in patients with normal spirometry results.

Methacholine challenge studies are often conducted to diagnose asthma in patients with mild or intermittent respiratory symptoms when screening spirometry results are normal. We hypothesized that in patients with increased nonspecific bronchial hyperreactivity (NSB-HR), gas trapping might be present and that this information could be a factor in clinical decision making. To assess the relations...

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Differences in Delay, but not Probability Discounting, in Current Smokers, E-cigarette Users, and Never Smokers

Steeper delay discounting in substance abuse populations, compared to non-abusing populations, has been well-established in prior studies. Despite the growing interest in e-cigarettes as a novel and relatively understudied form of nicotine consumption, relatively little is known as to how e-cigarette users discount rewards compared to traditional cigarette smokers and never smokers. In the pres...

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ژورنال

عنوان ژورنال: European Respiratory Journal

سال: 2017

ISSN: 0903-1936,1399-3003

DOI: 10.1183/13993003.00345-2016